The Trp719Arg allele of KIF6 rs20455, a putative risk factor for CHD especially in those with elevated low-density lipoprotein\r\ncholesterol (LDL-C), was investigated in Filipino-American women (FAW, ?? = 235) participating in health screenings in four\r\ncities. The rs20455 genotype of each subject was determined by a multiplex assay using a Luminex-OLA procedure. The risk\r\nallele Trp719Arg was present in 77% of the subjects. The genotype distribution was 23% Trp/Trp, 51% Arg/Trp, and 26% Arg/Arg.\r\nGenotype did not predict the presence of CHD risk factors. Moreover, LDL-C, HDL-C, and triglycerides mean values did not\r\nvary as a function of genotype. However, those with the Arg/Arg genotype on statin medication exhibited a significantly higher\r\nmean triglycerides level (?? < 0.01). Approximately 60% of participants regardless of genotype exhibited LDL-C levels =100mg/dL\r\nbut were not taking medication. Approximately 43% of those with the Trp719Arg risk allele on statins exhibited elevated LDL-C\r\nlevels. Our study suggests that the Trp719Arg allele of KIF 6 rs20455 is common among Filipino-American women; thus, even with\r\nborderline LDL-C levels would benefit from statin treatment. Secondly, many participants did not exhibit guideline recommended\r\nLDL-C levels including many who were on statin drugs.
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